Harrison’s Principles of Internal Medicine, 19E-2015 book pdf

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CONTRIBUTORS …….

……. xix ……… xxxvii

۲۲ Back and Neck Pain ….

John W. Engstrom, Richard A. Devo

PART 1 General Considerations in

I

۲۴ Fever and Rash

Elaine T. Kaye, Kenneth M. Kaye 25e Atlas of Rashes Associated with Fever. …….

Decision-Making in Clinical Medicine Daniel B. Mark, John B. Wong Screening and Prevention of Disease

NERVOUS SYSTEM DYSFUNCTION

Mark F. Walker, Robert B. Daroff

Shalender Bhasin, Shehzad Basaria 8 Medical Disorders During Pregnancy……….

Jeffrey M. Gelfand, Vanja C. Douglas Neurologic Causes of Weakness and Paralysis …..

۹ Medical Evaluation of the Surgical Patient…….

Numbness, Tingling, and Sensory Loss……………

Palliative and End-of-Life Care…

Clinical Problems of Aging….

۳۳e Video Library of Gait Disorders. …….. Gail Kang. Nicholas B. Galifianakis, Michael D. Geschwind

۱۲e The Safety and Quality of Health Care…….

  1. Andrew Josephson, Bruce L. Miller

۱۳e Primary Care in Low-and

Tim Evans, Kumanan Rasanathan

Aphasia, Memory Loss, and Other Focal

Integrative Health Practices…… Josephine P. Briggs

…..

Joseph P. Newhouse 16e Racial and Ethnic Disparities in

۳۷e Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral Disorders Maria Luisa Gorro-Tempini, Jennifer Ogar, Joel Kramer, Bruce L. Miller, Gil Rabinovici, Maria Carmela Tartaglia

Joseph R. Betancourt, Alexander R. Green 17e Ethical Issues in Clinical Medicine………….

Charles A. Czeisler, Thomas E. Scammell, Clifford B. Saper

DISORDERS OF EYES, EARS, NOSE, AND THROAT

PART 2 Cardinal Manifestations and

۴۰e Use of the Hand-Held Ophthalmoscope ……. 211

۴۱e Video Library of Neuro-Ophthalmology …….

۱۸ Pain: Pathophysiology and Management………..

۴۳ Disorders of Hearing ….

Danny O. Jacobs, William Silen

۴۴ Sore Throat, Earache, and Upper

Respiratory Symptoms Michael A. Rubin, Larry C. Ford, Ralph Gonzales

vill

۴۵

Oral Manifestations of Disease …………….. 235

۶۸ Hirsutism..

۴۶e Atlas of Oral Manifestations of Disease…….. 242 Samuel C. Durso, Janet A. Yellowitz

۶۹ Menstrual Disorders and Pelvic Pain

ALTERATIONS IN CIRCULATORY AND RESPIRATORY FUNCTIONS

ALTERATIONS IN THE SKIN

۷۰ Approach to the Patient with a Skin Disorder……. 339

Patricia A. Kritek, Christopher H. Fanta

۷۱ Eczema, Psoriasis, Cutaneous Infections, Acne,

Leslie P. Lawley, Calvin O. McCall, Thomas J. Lawley Skin Manifestations of Internal Disease ……… 353

۷۲

Eugene Braunwald, Joseph Loscalzo 51e Approach to the Patient with a Heart

۷۳ Immunologically Mediated Skin Diseases……….

۷۴ Cutaneous Drug Reactions ……..

Kanade Shinkai, Robert S. Stern, Bruce U. Wintroub 75 Photosensitivity and Other Reactions to Light……. 385

Alexander G. Marneros, David R. Bickers 76e Atlas of Skin Manifestations of Internal Disease…. Thomas J. Lawley, Calvin O. McCall, Robert A. Swerlick

Nausea, vomiting, and Indigestion.

Michael Camilleri, Joseph A. Murray

Russell G. Robertson, J. Larry Jameson Gastrointestinal Bleeding ……….

Savio John, Daniel S. Pratt Abdominal Swelling and Ascites. Kathleen E. Corey, Lawrence S. Friedman

۲۸۵

Patrick H. Henry, Dan L. Longo 80 Disorders of Granulocytes and Monocytes……… 413

Steven M. Holland, John I. Gallin

ALTERATIONS IN RENAL AND URINARY TRACT FUNCTION

Peripheral Blood Smears….

۶۰e Dysuria, Bladder Pain, and the Interstitial Cystitis/Bladder Pain Syndrome…………….. 288

Julie Lin, Bradley M. Denker

  1. Larry Jameson, Peter Kopp 83e Chromosome Disorders ………………. 445 Nancy B. Spinner, Laura K. Conlin The Practice of Genetics in Clinical Medicine……. 446 Susan M. Domchek, J. Larry Jameson, Susan Miesfeldt 85e Mitochondrial DNA and Heritable Traits

۶۴e Fluid and Electrolyte Imbalances and Acid-Base Disturbances: Case Examples……….. David B. Mount, Thomas D. Du Bose, Ir. Hypercalcemia and Hypocalcemia …………… 313

Karl Skorecki, Doron Behar 86e The Human Microbiome …. Jeffrey I. Gordon, Rob Knight 87e Network Medicine: Systems Biology in

۶۶ Acidosis and Alkalosis.

ALTERATIONS IN SEXUAL FUNCTION AND REPRODUCTION

۱۰۸

Breast Cancer ………….

Upper Gastrointestinal Tract Cancers ………….

۸۹e Hematopoietic Stem Cells

Tumors of the Liver and Biliary Tree………….

Endocrine Tumors of the Gastrointestinal Tract

Bladder and Renal Cell Carcinomas …………..

Howard I. Scher, Jonathan E. Rosenberg, Robert). Motzer 115 Benign and Malignant Diseases

CONTENTS

Howard I. Scher, James A. Eastham

Robert J. Motzer, Darren R. Feldman, George J. Bos!

۹۳e World Demography of Aging Richard M. Suzman, John G. Haaga 94e The Biology of Aging Rafael de Cabo, David G. Le Couteur

Lisa M. DeAngelis, Patrick Y. Wen

۹۵e Nutrient Requirements and Dietary

Shreyaskumar R. Patel, Robert S. Benjamin 120e Carcinoma of Unknown Primary ………… 608 Gauri R. Varadhachary, James L. Abbruzzese

………… ۶۰۸

Paraneoplastic Neurologic Syndromes and

۹۷ Malnutrition and Nutritional Assessment……..

۹۸e Enteral and Parenteral Nutrition Therapy…… 465 Bruce R. Bistrian, L John Hoffer, David F. Driscoll

۱۲۴e Neoplasia During Pregnancy…………..

PARI

Oncology and Hematology

۱۲۵ Late Consequences of Cancer and Its Treatment…. 620

۹۹ Approach to the Patient with Cancer …………. 467

۱۲۶ Iron Deficiency and Other Hypoproliferative

۱۰۰ Prevention and Early Detection of Cancer ……… 475

Jennifer M. Croswell, Otis W. Brawley, Barnett S. Kramer

۱۲۷

Disorders of Hemoglobin ……

Megaloblastic Anemias……………………

Patl. Morin, Jeffrey M. Trent, Francis S. Collins, Bert Vogelstein 102e Cancer Cell Biology. ……………….. Jeffrey W. Clark, Dan L Longo 103e Principles of Cancer Treatment………….. Edward A. Sausville, Dan L. Longo Infections in Patients with Cancer

Hemolytic Anemias and Anemia Due to

Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia……………….. 662

Cancer of the Skin Walter 1. Urba, Brendan D. Curti

Polycythemia Vera and Other Myeloproliferative Neoplasms

Neoplasms of the Lung

۱۳۲ Acute Myeloid Leukemia

Guido Marcucci, Clara D. Bloomfield

Hagop Kantarjian, Jorge Cortes

۱۳۵e Less Common Hematologic Malignancies…..

Infectious Arthritis …

Nikhil C. Munshi, Dan L. Longo, Kenneth C Anderson

۱۵۹ Intraabdominal Infections and Abscesses……….

۱۳۸e Transfusion Biology and Therapy …………. Jeffery S. Dzieczkowski, Kemeth C. Anderson 139e Hematopoietic Cell Transplantation ………

Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning …. Regina C. LaRocque, Edward T. Ryan, Stephen B. Calderwood Clostridium difficile Infection, Including

DISORDERS OF HEMOSTASIS

۱۶۲

Dale N. Gerding, Stuart Johnson Urinary Tract Infections, Pyelonephritis,

۱۴۰ Disorders of Platelets and Vessel Wall

………… ۷۲۵

Kalpana Gupta, Barbara W. Trautner 163 Sexually Transmitted Infections: Overview

and Clinical Approach….

Valder R. Arruda, Katherine A. High

Meningitis, Encephalitis, Brain Abscess,

Jane E. Freedman, Joseph Loscalzo 143 Antiplatelet, Anticoagulant, and

۱۶۶e Infectious Complications of Burns……….. 911 Lawrence C. Madoff, Florencia Pereyra 167e Infectious Complications of Bites ……….. 911 Lawrence C. Madoff, Florencia Pereyra

۱۴۴ Approach to the Patient with an

CLINICAL SYNDROMES: HEALTH CARE-ASSOCIATED INFECTIONS

۷۰۱۱۶۸ Infections Acquired in Health Care Facilities. ……. 911 Robert A. Weinstein

۹۱۹

۱۴۵e Molecular Mechanisms of Microbial Pathogenesis… Gerald B. Pier

Roby P. Bhattacharyya, Yonatan H. Grad, Deborah T. Hung

APPROACH TO THERAPY FOR BACTERIAL DISEASES

۱۷۰

Treatment and Prophylaxis of Bacterial Infections… 930 David C. Hooper, Erica S. Shenoy, Christy A. Varughese

Immunization Principles and Vaccine Use ………

DISEASES CAUSED BYGRAM-POSITIVE BACTERIA

Health Recommendations for International

Pneumococcal Infections

Jay S. Keystone, Phyllis E. Kozarsky

Streptococcal Infections…

Alexander J. McAdam, Andrew B. Onderdonk 151e Climate Change and Infectious Disease…….

۱۵۲e Infections in Veterans Returning from

Enterococcal Infections. Cesar A. Arias, Barbara E. Murray Diphtheria and Other Corynebacterial Infections…. 977 William R. Bishai, John R. Murphy Listeria monocytogenes Infections …………… 982 Elizabeth L. Hohmann, Daniel A. Portnoy

CLINICAL SYNDROMES: COMMUNITY-ACQUIRED INFECTIONS

Lionel A. Mandell, Richard G. Wunderink

Rebecca M. Baron, Miriam Baron Barshak

۱۷۹ Gas Gangrene and Other Clostridial Infections. . . . . . 990

Amy E. Bryant, Dennis L. Stevens

DISEASES CAUSED BY GRAM-NEGATIVE BACTERIA

Meningococcal Infections

……..

۹۹۵

۲۰۶

Syphilis Sheila A. Lukehart 207e Endemic Treponematoses.

Gonococcal Infections..

۱۱۴۰

Haemophilus and Moraxella Infections……….. 1010 Timothy F. Murphy 183e Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria ………. 1014 Tamar F. Barlam, Dennis L. Kasper

Rudy A. Hartskeerl, Jiři F. P. Wagenaar 209 Relapsing Fever …

Alan G. Barbour Lyme Borreliosis. …

.

…….. ۱۱۴۹

Victor L Yu, M. Luisa Pedro-Botet, Yusen E Lin Pertussis and Other Bordetella Infections……..

DISEASES CAUSED BY RICKETTSIAE, MYCOPLASMAS,

Diseases Caused by Gram-Negative

Thomas A. Russo, James R. Johnson

Rickettsial Diseases… David H. Walker, J. Stephen Dumler, Thomas Marrie Infections Due to Mycoplasmas

……….. ۱۰۳۶

۲۱۲

Helicobacter pylori Infections

Charlotte A. Gaydos, Thomas C. Quinn

VIRAL DISEASES: GENERAL CONSIDERATIONS

۲۱۵e Antiviral Chemotherapy, Excluding

Philippe J. Sansonetti, Jean Bergounioux

INFECTIONS DUE TO DNA VIRUSES

Related Organisms …. Martin J. Blaser Cholera and Other Vibrioses…. Matthew K. Waldor, Edward T. Ryan

۲۱۶

Herpes Simplex Virus Infections……………. 1175

۲۱۷

Varicella-Zoster Virus Infections……………. 1183

Richard F. Jacobs, Gordon E. Schutze Plague and Other Yersinia Infections ………….

Epstein-Barr Virus Infections, including Infectious Mononucleosis..

Cytomegalovirus and Human Herpesvirus

Michael Giladi, Moshe Ephros

۲۲۰e Molluscum Contagiosum, Monkeypox,

……… ۱۰۸۳

MISCELLANEOUS BACTERIAL INFECTIONS

Aaron C. Ermel, Darron R. Brown

Actinomycosis and Whipple’s Disease……….. 1088

INFECTIONS DUE TO DNA AND RNA RESPIRATORY VIRUSES

۲۲۳ Common Viral Respiratory Infections………… 1202

Ronit Cohen-Poradosu, Dennis L. Kasper

Yehuda Z. Cohen, Raphael Dolin

INFECTIONS DUE TO HUMAN IMMUNODEFICIENCY VIRUS AND OTHER HUMAN RETROVIRUSES

…………… ۱۱۲۲

۲۲۵e The Human Retroviruses…………….. 1215

Nontuberculous Mycobacterial Infections ………1128

۲۰۵e Antimycobacterial Agents

xii

۲۲۶ Human Immunodeficiency Virus Disease: AIDS

……….. ۱۳۸۴

Edouard G. Vannier, Peter J. Krause

Nicholas J. White, Joel G. Breman

Viral Gastroenteritis Umesh D. Parashar, Roger I. Glass Enterovirus, Parechovirus, and Reovirus

Chagas Disease and African Trypanosomiasis ….. 1394

۱۳۹۸

Toxoplasma Infections ……………….. Kami Kim, Lloyd H. Kasper Protozoal Intestinal Infections and

۲۳۰e Rubella (German Measles) Laura A. Zimmerman, Susan E Reef

Peter F. Weller

Steven A. Rubin, Kathryn M. Carbone Rabies and Other Rhabdovirus infections. . . . . . . .. 1299

HELMINTHIC INFECTIONS

Arthropod-Borne and Rodent-Borne

۲۵۵e Introduction to Helminthic Infections……. 1409

Trichinellosis and Other Tissue Nematode

FUNGAL INFECTIONS

Intestinal Nematode Infections…. Peter F. Weller, Thomas B. Nutman

Diagnosis and Treatment of Fungal Infections….. 1329

۲۵۸

Filarial and Related Infections …………….. 1417

Charles H. King, Adel A. F. Mahmoud

Chadi A. Hage, L. Joseph Wheat Coccidioidomycosis ……………………. 1334

………….. ۱۴۳۰

  1. Clifford Lane, Anthony S. Fauci

Mucormycosis..

Charles G. Hurst, Jonathan Newmark, James A. Romano, Ir. 263e Radiation Terrorism Christine E. Hill-Kayser, Eli Glatstein, Zelig A. Tochner

۲۴۴ Pneumocystis Infections…

Henry Masur, Alison Morris

PART 10 Disorders of the

PROTOZOAL AND HELMINTHIC INFECTIONS: GENERAL

INTRODUCTION TO CARDIOVASCULAR DISORDERS

۲۴۵e Laboratory Diagnosis of Parasitic

۲۶۴ Approach to the Patient with Possible

Joseph Loscalzo 265e Basic Biology of the Cardiovascular

۲۴۶e Agents Used to Treat Parasitic Infections …. 1363

Joseph Loscalzo, Peter Libby, Jonathan A. Epstein 266e Epidemiology of Cardiovascular Disease…. 1442

PROTOZOAL INFECTIONS

۲۴۷ Amebiasis and Infection with Free-Living

……… ۱۳۶۳

۲۶۷ Physical Examination of the Cardiovascular

Patrick T. O Gara, Joseph Loscalzo

……… ۱۴۵۰

۲۹۲e Atlas of Atherosclerosis. …………….. 1578

xiii

……….. ۱۴۵۹

۲۹۳ Ischemic Heart Disease….

……… ۱۵۷۸ Elliott M. Antman, Joseph Loscalzo 294 Non-ST-Segment Elevation Acute Coronary

Syndrome (Non-ST-Segment Elevation Myocardial

Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography

Marcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon

Christopher P. Cannon, Eugene Braunwald 295 ST-Segment Elevation Myocardial Infarction…… 1599

Marcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon Diagnostic Cardiac Catheterization and

۲۹۶e Percutaneous Coronary Interventions and

CONTENTS

۲۹۷e Atlas of Percutaneous Revascularization …. 1611 Jane A. Leopold, Deepak L. Bhatt, David P. Faxon Hypertensive Vascular Disease Theodore A. Kotchen Renovascular Disease…. Stephen C. Textor

۲۷۳e Principles of Electrophysiology………… 1466 David D. Spragg, Gordon F. Tomaselli

۲۹۹ ۲۹۹

David D. Spragg, Gordon F. Tomaselli The Bradyarrhythmias: Disorders of the

Thromboembolism Samuel Z. Goldhaber Diseases of the Aorta

۳۰۲ Arterial Diseases of the Extremities ………….

Supraventricular Tachyarrhythmias……….. Gregory F. Michaud, William G. Stevenson Ventricular Arrhythmias…. Roy M. Jolin, William G. Stevenson

۳۰۳ Chronic Venous Disease and Lymphedema……. 1650

Mark A. Creager, Joseph Loscalzo

۲۷۹ Heart Failure: Pathophysiology and Diagnosis….. 1500

Douglas L. Mann, Murali Chakinala 280 Heart Failure: Management ..

DIAGNOSIS OF RESPIRATORY DISORDERS

Cardiac Transplantation and Prolonged Assisted

۳۰۵ Approach to the Patient with Disease of the

۱۶۶۱

Patricia A. Kritek, Augustine M. K. Choi

Sharon A. Hunt, Hari R. Mallidi Congenital Heart Disease in the Adult ……….. 1519

.

۱۶۶۳

Diagnostic Procedures in Respiratory Disease Anne L. Fulbrigge, Augustine M. K. Choi 308e Atlas of Chest Imaging Patricia A. Kritek, John J. Reilly, Jr.

DISEASES OF THE RESPIRATORY SYSTEM

Tricuspid and Pulmonic Valve Disease……….. 1547 Patrick T. O Gara, Joseph Loscalzo Multiple and Mixed Valvular Heart Disease……. 1550 Patrick T. O’Gara, Joseph Loscalzo Cardiomyopathy and Myocarditis ………….. 1553 Neal K. Lakdawala, Lynne Warner Stevenson, Joseph Loscalzo

Peter J. Barnes 310 Hypersensitivity Pneumonitis and Pulmonary

Infiltrates with Eosinophilia. Praveen Akut hota, Michael E. Wechsler Occupational and Environmental Lung

۲۸۹e Tumors and Trauma of the Heart ………. 1577

۲۹۰e Cardiac Manifestations of Systemic Disease. . 1577 Eric H. Awtry, Wilson S Colucci

Rebecca M. Baron, Miriam Baron Barshak

CORONARY AND PERIPHERAL VASCULAR DISEASE

۳۱۴ Chronic Obstructive Pulmonary Disease……….

John J. Reilly, Ir. Edwin K. Silverman, Steven D. Shapiro

Interstitial Lung Diseases…..

۱۷۰۸

۳۳۵

Chronic Kidney Disease … Joanne M. Bargman, Karl Skorecki Dialysis in the Treatment of Renal Failure . . . . . . . . 1822

….. ۱۷۱۶

۳۳۶

Richard W. Light

۱۷۱۹

۳۳۷

Transplantation in the Treatment of Renal Failure … Jamil Azzi, Edgar L. Milford, Mohamed H. Sayegh.

John F. McConville, Babak Mokhilesi, Julian Solway

Andrew Wellman, Susan Redline

Judia B. Lewis, Eric G. Neilson Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development… 1850

CONTENTS

Tubulointerstitial Diseases of the Kidney …….. 1856 Laurence H. Beck, David J. Salant

Nelson Leung, Stephen C. Textor

Approach to the Patient with Critical illness……. 1729

۳۴۳

Urinary Tract Obstruction….

Acute Respiratory Distress Syndrome………….. 1736

DISORDERS OF THE ALIMENTARY TRACT

Approach to the Patient with Shock. ………… 1744 Ronald V. Maier Severe Sepsis and Septic Shock …………..

William L. Hasler, Chung Ow yang Gastrointestinal Endoscopy,

Cardiogenic Shock and Pulmonary Edema…….. Judith S. Hochman, David H. Ingbar Cardiovascular Collapse, Cardiac Arrest, and

۳۴۶e Video Atlas of Gastrointestinal Endoscopy … 1900

Louis Michel Wong Ke Song, Mark Topazian 347 Diseases of the Esophagus…..

NEUROLOGIC CRITICAL CARE

۳۴۸ Peptic Ulcer Disease and Related Disorders ……. 1911

Coma ……..

۳۲۹e Examination of the Comatose patient……. 1777 S. Andrew Josephson Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy, and Subarachnoid Hemorrhage…..

……. ۱۷۷۷ J. Claude Hempill, III, Wade S. Smith, Daryl R. Gress

Inflammatory Bowel Disease….

۳۵۲

Diverticular Disease and Common

ONCOLOGIC EMERGENCIES

۳۳۱ Oncologic Emergencies …

Rasim Gucalp, Janice P. Dutcher

۳۵۴ Mesenteric Vascular Insufficiency…………… 1978

Rizwan Ahmed, Mahmoud Malas 355 Acute Intestinal Obstruction………………. 1981

Danny O. Jacobs

۳۳۲e Cellular and Molecular Biology

LIVER AND BILIARY TRACT DISEASE

۱۷۰۰

۳۳۳e Adaptation of the Kidney to Injury Joseph V. Bonventre

۳۵۷ Approach to the Patient with Liver Disease……. 1989

Marc G. Ghany, Jay H. Hoofnagle

۳۵۹ The Hyperbilirubinemias …..

Allan W. Wolkoff

۳۸۲ Systemic Sclerosis (Scleroderma) and

Toxic and Drug-Induced Hepatitis …………..2023

Haralampos M. Moutsopoulos, Athanasios G. Tzioufas

Joel D. Taurog, Jolu D. Carter

Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis Manal F. Abdelmalek, Anna Mae Diehl

۳۸۵ The Vasculitis Syndromes

Carol A. Langford, Anthony S. Fauci 386e Atlas of the Vasculitic Syndromes……….

CONTENTS

Jules L Dienstag, Atul K. Bhan 367e Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver…

Behçet’s Syndrome. . . . . . . . . . . . . . . . . . . . . . . . . . 2194

Haralampos M. Moutsopoulos 388 Polymyositis, Dermatomyositis, and Inclusion

۲۰۶۷

۳۸۹ Relapsing Polychondritis

۳۶۹ Diseases of the Gallbladder and Bile Ducts…….. 2075

Norton J. Greenberger, Gustav Paumgartner

۳۹۲ Familial Mediterranean Fever and Other

Hereditary Autoinflammatory Diseases……….2212

۳۷۰ Approach to the Patient with Pancreatic Disease … 2086

Darwin L. Conwell, Norton). Greenberger, Peter A. Banks 371 Acute and Chronic Pancreatitis……

Darwin L. Conwell, Peter A. Banks, Norton J. Greenberger

DISORDERS OF THE JOINTS AND ADJACENT TISSUES

.

PART 15 Immune-Mediated,

Inflammatory, and

Disorders

۳۹۵ Gout and Other Crystal-Associated

……….. ۲۲۳۳

۳۷۲e Introduction to the Immune System ……. 2103

  1. Ralph Schumacher, Lan X. Chen

۳۷۳e The Major Histocompatibility Complex…… 2103

۳۹۷

Arthritis Associated with Systemic Disease,

Primary Immune Deficiency Diseases………… 2103

۳۷۵e Primary Immunodeficiencies Associated

۳۹۸ Periarticular Disorders of the Extremities……..

Carol A. Langford

PART 16 Endocrinology and

۳۷۷e Autoimmunity and Autoimmune Diseases… 2124

۳۹۹ Approach to the Patient with Endocrine

Systemic Lupus Erythematosus ..

۴۰۰e Mechanisms of Hormone Action …….. 2255 J. Larry Jameson 401e Anterior Pituitary: Physiology of

Haralampos M. Moutsopoulos, Panayiotis G. Vlachoyannopoulos

۴۲۵

۴۰۲ Hypopituitarism…

…… ۲۲۵۵ Shlomo Melmed. J. Larry Jameson Anterior Pituitary Tumor Syndromes ………… 2261

Osteoporosis ………. Robert Lindsay, Felicia Cosman 426e Paget’s Disease and Other Dysplasias

Murray). Favus, Tamara J. Vokes

  1. Larry Jameson, Susan). Mandel, Anthony P. Weetman Disorders of the Adrenal Cortex………

۴۲۷ Heritable Disorders of Connective Tissue……..2504

Pheochromocytoma… Hartmut P. H. Neumann

Hemochromatosis

۴۰۹ Autoimmune Polyendocrine Syndromes ……..

Peter A. Gottlieb

REPRODUCTIVE ENDOCRINOLOGY

Christopher M. Burns, Robert L. Wortmann

۴۱۰ Disorders of Sex Development..

John C. Achermann, J. Larry Jameson Disorders of the Testes and Male Reproductive System ….

Robert ). Hopkin, Gregory A. Grabowski 433e Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate

Disorders of the Female Reproductive System…. 2375

Menopause and Postmenopausal Hormone

Priya S. Kishnani, Yuan-Tsong Chen 434e Inherited Disorders of Amino Acid

JoAnn E. Manson, Shari S. Bassuk

Nicola Longo 435e Inherited Defects of Membrane Transport … 2534

۴۳۶e Atlas of Clinical Manifestations of Metabolic Diseases….

Jeffrey S. Flier, Eleftheria Maratos-Flier

Evaluation and Management of Obesity. ……… 2392

DIAGNOSIS OF NEUROLOGIC DISORDERS

۴۱۸ Diabetes Mellitus: Management and Therapies…. 2407

۴۳۷ Approach to the Patient with Neurologic Disease… 2535

Daniel H. Lowenstein, Joseph B. Martin, Stephen L. Hauser 438e The Neurologic Screening Exam ……….. 2540

Diabetes Mellitus: Complications

۲۴۲۲

۴۳۹e Video Atlas of the Detailed Neurologic

Martin A. Samuels 440e Neuroimaging in Neurologic Disorders……

Disorders of Lipoprotein Metabolism. ……….. 2435 Daniel J. Rader, Helen H. Hobbs The Metabolic Syndrome

Andre D. Furtado, William P. Dillon 442e Electrodiagnostic Studies of Nervous System Disorders: EEG, Evoked Potentials, and EMG …… 2541

DISORDERS OF BONE AND MINERAL METABOLISM

۴۲۳ Bone and Mineral Metabolism in Health

۴۴۳e Technique of Lumbar Puncture………… 2541 Elizabeth Robbins, Stephen L. Hauser 444e Biology of Neurologic Diseases…………

۴۲۴ Disorders of the Parathyroid Gland and

DISEASES OF THE CENTRAL NERVOUS SYSTEM

Jolun T. Potts, Jr., Harald Jüppner

۴۶۹e Cocaine and Other Commonly

Nancy K. Mello, Jack H. Mendelson

Cerebrovascular Diseases……. Wade S. Smith, S. Claiborne Johnston, J. Claude Hemphill, III Migraine and Other Primary Headache Disorders.. Peter J. Goadsby, Neil H. Raskin Alzheimer’s Disease and Other Dementias…….. 2598 William W. Seeley, Bruce L. Miller Parkinson’s Disease and Other Movement

…………….. ۲۷۲۹

  1. Warren Olanow, Anthony H. V. Schapira, Jose A. Obeso

PART 18 Poisoning, Drug Overdose,

and Envenomation 472e Heavy Metal Poisoning ……………… 2733

Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases

۴۷۳e Poisoning and Drug Overdose …………

Disorders Caused by Venomous Snakebites and Marine Animal Exposures Charles Lei, Natalie J. Badowski, Paul S Auerbach,

Disorders of the Autonomic Nervous System…… 2637 Phillip A. Low, Jolm W. Engstrom Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders…

۲۶۴۵

Richard J. Pollack, Scott A. Norton

Stephen L. Hauser, Allan H. Ropper

PART 19 Disorders Associated with

Environmental Exposures

۴۵۸ Multiple Sclerosis and Other Demyelinating

Stephen L. Hauser, Douglas S. Goodin

۴۷۷e Hyperbaric and Diving Medicine……….. Michael H. Bennett, Simon) Mitchell 478e Hypothermia and Frostbite………….. Daniel F. Danzl 479e Heat-Related illnesses. …

APPENDIX: Laboratory Values of Clinical Importance. … 2754

Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies… Stephen L. Hauser, Anthony A. Amato Myasthenia Gravis and Other Diseases of the Neuromuscular Junction… Daniel B. Drachman, Anthony A. Amato 462e Muscular Dystrophies and Other Muscle Diseases Anthony A. Amato, Robert H. Brown, Ir. 463e Special Issues in Inpatient Neurologic

۴۸۱e Clinical Procedure Tutorial: Central Venous Catheter Placement………………. 2770 Maria A. Yialamas, William E. Corcoran, Gyorgy Frend,

۴۸۲e Clinical Procedure Tutorial: Thoracentesis…. 2770

۴۸۳e Clinical Procedure Tutorial: Abdominal

Maria A. Yialamas, Anna E. Rutherford, Lindsay King

Charles A. Morris, Emily Page Nelson

PSYCHIATRIC AND ADDICTION DISORDERS

Arterial Blood Gas Sampling………………. 2770

۴۶۵e Biology of Psychiatric Disorders ……….

۴۶۸e Opioid-Related Disorders….

FIG. 293-2

Evaluation of the patient with known or

FIG. 293-3 Management of the patient with ischemic

of delirium in hospitalized older patients ……. 79

Algorithm for evaluation and management

FIG. 295-5

The assessment of need for implantation of

ALLERGY, IMMUNOLOGY, RHEUMATOLOGY

FIG. 378-2

The diagnosis and initial therapy of systemic

FIG. 383-1

Treatment for Sjögren’s syndrome…………..

FIG. 84-2

Approach to genetic testing…………… 448

diagnosis of vasculitis

FIG. 390-9

Management of acute sarcoidosis………..

FIG. 393-1 FIG. 393-2

The diagnosis of musculoskeletal complaints. … The consideration of the most common

FIG. 393-6

Approach to synovial fluid aspiration

Clinical conditions in which a decrease in cardiac

FIG. 295-4

Reperfusion therapy for patients with T-segment

metal stents, drug-eluting stent, or CABG…. 296e-3

DISORDERS OF THE URINARY TRACT

FIG. 337-2

Typical algorithm for early posttransplant care

in patients undergoing noncardiac surgery …… 52 Strategy for evaluating heart murmurs ……. 51e-8

FIG. 51 e-9

EMERGENCY AND CRITICAL CARE

FIG. 276-9

Treatment algorithm for patients presenting

radiation casualties……………….. 263e-4

supraventricular tachycardia …….. Management strategy for patients with

FIG. 283-6

Management of patients with aortic

FIG. 322-5

Algorithm for the initial management of acute respiratory distress syndrome ………. 1739

FIG. 284-1

Management of rheumatic mitral stenosis……

FIG. 285-1

Management of tricuspid regurgitation……..

FIG. 327-3B Cardiac arrest management: bradyarrhythmia/

FIG. 365-3 FIG. 365-5

Management of recurrent variceal hemorrhage..2064 Treatment of refractory ascites…………..2065

FIG. 68-2

The evaluation and differential diagnosis

FIG. 402-1 Management of adult growth hormone (GH)

FIG. 77-17 FIG. 77-18

The physiologic classification of anemia ……. An approach to diagnosing patients with

FIG. 403-3 Management of prolactinoma……….

FIG. 403-7 Management of a nonfunctioning

Evaluation of a patient with cervical adenopathy … Algorithm for management of non-small-cell

FIG. 405-13 Approach to the patient with a thyroid

FIG. 406-10 Management of the patient with suspected

Algorithm for management of small-cell lung

FIG. 406-12 Diagnostic flowchart for evaluating patients

FIG. 107-6

Approach to a solitary pulmonary nodule ……

FIG. 406-13 Management of the patient with an incidentally

FIG. 107-8

FIG. 406-16 Diagnostic flowchart for evaluating patients

Approach to first-line therapy in a patient with stage IV non-small-cell lung cancer ……

FIG. 108-2

The “triple diagnosis” technique in suspected

FIG. 411-6 FIG. 416-1

Evaluation of hypogonadism…. Algorithm for the treatment of obesity

FIG. 108-3

Management of a breast cyst

hepatocellular carcinoma..

FIG. 419-4 FIG. 420-2

Screening for microalbuminuria………… Hypoglycemia-associated autonomic failure in insulin-deficient diabetes…………

poorly differentiated adenocarcinoma of

FIG. 428-3

Algorithm for screening for HFE-associated

FIG. 127-3

Pathophysiology of sickle cell crisis. ………. 634 The therapy of newly diagnosed acute

FIG. 53-2

Approach to the patient with dysphagia …….

and determination of type ………… FIG. 140-2 Evaluating the thrombocytopenic patient…… FIG. 143-1 Classification of antithrombotic drugs …….. FIG. 331-2 Management of cancer patients with back pain… 1791 FIG. 331-4 Management of patients at high risk for the

FIG. 57-1

Management of acute upper gastrointestinal

Evaluation of the patient with jaundice …… FIG. 348-12 Overview of new-onset dyspepsia……….. FIG. 357-1 Algorithm for evaluation of abnormal

FIG. 152-1 Syndromic approach to differential diagnosis

of suspected infection in a veteran who has

FIG. 363-2

Treatment algorithm for alcoholic hepatitis. . . . . 2054

FIG. 159-3 Management of patients with intraabdominal

abscesses using percutaneous drainage …….. 850

FIG. 445-2

complications of bacterial meningitis. Evaluation of the adult patient with a

FIG. 445-3

FIG. 162-4

Diagnostic approach to urinary tract infection … 865

Medical management of stroke and transient

colonization with Helicobacter pylori and diseases of the upper gastrointestinal tract

Treatment algorithm for the management

Therapeutic decision-making for multiple

FIG. 188-2

Management of Helicobacter pylori

FIG. 459-1

Approach to the evaluation of peripheral

FIG. 206-4

Interpretation of results from syphilis enzyme

FIG. 209-3 FIG. 210-2

Treatment of relapsing fever ………. Treatment of the various early or late

FIG. 462e-1 Diagnostic evaluation of intermittent

FIG. 462e-2 Diagnostic evaluation of persistent

FIG. 466-1 Medical management of major

FIG. 226-36 Evaluation of diarrhea in patients with

HIV infection.. FIG. 232-5 Rabies postexposure prophylaxis

FIG. 47e-2

The evaluation of the patient with dyspnea…. 47e-3

thromboembolism and deep venous thrombosis ……………………… 1632 Imaging tests to diagnose deep venous

FIG. 300-6

FIG. 61-4 FIG. 63-5 FIG. 63-6 FIG. 63-7 FIG. 63-8

Approach to the patient with polyuria …….. The diagnostic approach to hyponatremia…… The diagnostic approach to hypernatremia ….. The diagnostic approach to hypokalemia …… The diagnostic approach to hyperkalemia …..

FIG. 300-7 Acute management of pulmonary

thromboembolism ………………… 1634 FIG. 316-1 Approach to the diagnosis of pleural effusions… 1717

FIG. 337-2

with erectile dysfunction……………… 327 A typical algorithm for early posttransplant

FIG. 340-1

in the last days of terminally ill patients ………. 68

Algorithm for the treatment of allergic and other immune-mediated acute interstitial nephritis, … 1857 Diagnostic approach for urinary tract obstruction in unexplained renal failure. …………… 1873

FIG. 343-1

FIG. 43-2 FIG. 69-2

An algorithm for the approach to hearing loss… 218 Algorithm for evaluation of amenorrhea…… 337

FIG. 164-1

The management of patients with suspected

James L. Abbruzzese, MD Chief, Division of Medical Oncology, Department of Medicine; Associate Director, Clinical Research, Duke Cancer Institute, Durham, North Carolina

Valder R. Arruda, MD, PhD Associate Professor, Division of Hematology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia,

Associate Professor of Medicine, Division of Gastroenterology and Hepatology.

Andrew W. Artenstein, MD Professor of Medicine, Tufts University School of Medicine, Boston, Massachusetts: Adjunct Professor of Medicine and Health Services, Policy and Practice, Alpert Medical School, Brown University, Providence, Rhode Island: Chair, Department of Medicine, Baystate Health, Springfield, Massachusetts

Heart Disease Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California (282)

Wellcome Trust Senior Research Fellow in Clinical Science, University College London; Professor of Paediatric Endocrinology, UCL Institute of Child Health, University College London, London, United Kingdom [410] John W. Adamson, MD Clinical Professor, Division of Hematology/Oncology, Department of

Professor and Director, Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina (92e] John C. Atherton, MD, FRCP Professor of Gastroenterology and Dean of the School of Medicine, University

University School of Medicine, Stanford, California [474]

General Surgery Resident, Department of General Surgery. Johns Hopkins Hospital, Baltimore, Maryland (353, 354)

AstraZeneca Professor of Respiratory and Inflammatory Diseases, Director, Inflammation and Allergic Diseases Research Section, Harvard Medical School: Brigham and Women’s Hospital, Boston, Massachusetts [376]

Assistant Professor of Medicine, Harvard Medical School; Beth Israel Deaconess Medical Center, Boston, Massachusetts (310)

Cardiology Division, Boston Medical Center, Boston, Massachusetts (289e,

Professor of Neurology, Harvard Medical School; Vice-Chairman, Department

Instructor in Medicine, Harvard Medical School; Associate Physician, Brigham

Professor of Neurology, School of Medicine, University of California, San Francisco, San Francisco, California (30, 31, 442e] Neil M. Ampel, MD Professor of Medicine, University of Arizona; Staff Physician, Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona [237]

James F. King, MD Endowed Chair in Gastroenterology: Professor of Internal Medicine, Saint Louis University Liver Center, Saint Louis University School of Medicine, St. Louis, Missouri (365, 367e] Lindsey R. Baden, MD Associate Professor of Medicine, Harvard Medical School: Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Boston, Massachusetts

Kraft Family Professor of Medicine, Harvard Medical School; Chief, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston,

Professor of Medicine, University of California, San Franciscos Professor, School of Public Health, University of California, Berkeley: Chief, Division of Occupational and Environmental Medicine, San Francisco General Hospital,

Professor of Medicine, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital; Associate Dean for Clinical Translational Research, Harvard Medical School, Boston, Massachusetts (293, 295)

Assistant Professor, Department of Genetics and Genomic Sciences, Mount

Director, Division of Clinical Research, Fred Hutchinson Cancer Research

Cesar A. Arias, MD, PhD, MSC

Professor of Medicine, Harvard Medical School: Senior Physician, Division of Gastroenterology, Brigham and Women’s Hospital, Boston, Massachusetts

Medical School at Houston, Houston, Texas, Director, Molecular Genetics and Antimicrobial Unit; Co-Director, International Center for Microbial Genomics, Universidad, El Bosque, Bogota, Colombia (174) Wiebke Arlt, MD, DSC, FRCP, FMedSci Professor of Medicine, Centre for Endocrinology, Diabetes and Metabolism,

Robert L. Barbieri, MD Kate Macy Ladd Professor of Obstetrics, Gynecology and Reproductive Biology. Harvard Medical School: Chair, Department of Obstetrics and

Alan G. Barbour, MD

Consultant Endocrinologist, University Hospital Birmingham, Birmingham,

Katrina Armstrong, MD, MS

Professor of Medicine, University of Toronto: Staff Nephrologist. University

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